{"id":16116,"date":"2026-04-28T11:41:14","date_gmt":"2026-04-28T11:41:14","guid":{"rendered":"https:\/\/davinci-center.eu\/new\/?page_id=16116"},"modified":"2026-04-28T18:33:41","modified_gmt":"2026-04-28T18:33:41","slug":"publications","status":"publish","type":"page","link":"https:\/\/davinci-center.eu\/new\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\t\t
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A study on tumour-infiltrang\nlymphocytes, PD-L1 and BRCA1 immunohistochemical expression in basal-like\nsubtype of breast cancer<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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\u00a0P. Dimitrova, S. Popovska, I. Ivanov<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Article Number: 479 (Suppl 1):S1\u2013S320; PS-02-009, S68 IF 3.5 Q1<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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27 August 2021<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Familial Lynch syndrome with early age of onset and confirmed splice site mutation in MSH2: A case report<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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Bogomilova Kamburova Z, Popovska S, Kovacheva K, Petrov K, Nikolova S.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Article Number: 39 IF 2.3 Q1<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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March 14, 2022<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Lynch syndrome (LS) is the most common hereditary cause of colorectal cancer (CRC), accounting for 3-5% of all CRC cases. LS was previously termed hereditary nonpolyposis CRC (HNPCC) to emphasize the absence of colon polyps and to distinguish it from the other types of hereditary CRC, which are characterized by the presence of polyps, such as Adenomatous Polyposis Coli and Hamartomatous Polyposis syndrome.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Morphological and Quantitative Evidence for Altered Mesenchymal Stem Cell Remodeling of Collagen in an Oxidative Environment\u2014Peculiar Effect of Epigallocatechin-3-Gallate<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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\u00a0Komsa-Penkova R., Stoycheva S, Tonchev P, Stavreva G, Todinova S, Georgieva G, Yordanova A, Kyurkchiev S, Altankov G<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Article Number: 3957. IF 4,207 Q1<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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22 September 2022<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Collagens are the most abundant proteins of the extracellular matrix (ECM) and are important for the mechanical properties of connective tissues, regulation of cell function, and communication. It recently became clear that they are also tightly involved in the regulation of adult stem cell functioning, such as renewal and differentiation.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Morphometric and Nanomechanical Features of Erythrocytes Characteristic of Early Pregnancy Loss\n<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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Komsa-Penkova R, Danailova A, Krumova S, Georgieva G., Giosheva I, Gartcheva L, Iliev I, Gartchev E, Kercheva K, Savov A, Todinova S<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Article Number: Int. J. Mol. Sci.2022, 23(15), 8764 IF 6.208 Q1<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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6 August 2022<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Early pregnancy loss (EPL) or fetal loss is a relatively common pathology. Some of the causes of fetal loss include chromosomal abnormalities, genetic syndromes, thrombophilia, infections, antiphospholipid syndrome, and maternal diseases such as diabetes and hypertension, and inflammation. Nevertheless, more than 50% of EPLs remain idiopathic. Despite a wide range of investigations, no specific biomarkers with a high predictive value of threatening pregnancy losses have been identified.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Morphometric and\nnanomechanical features of platelets from women with early pregnancy loss provide\nnew evidence of the impact of inherited thrombophilia<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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Komsa-Penkova R, Danailova A, Krumova S, Georgieva G., Giosheva I, Gartcheva L, Iliev I, Gartchev E, Kercheva K, Savov A, Todinova S<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Article Number: Int. J. Mol. Sci. 2022, 23, 4512. IF 6.208Q1<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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19 April 2022<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Early pregnancy loss (EPL) or spontaneous abortion is the most common complication of human reproduction, with an incidence ranging between 50\u201370% of all conceptions. EPL is usually associated with genetic or chromosomal abnormalities in the developing embryo, viral infections, immunological and immunogenic causes , thrombophilia, endocrine disorders , poorly controlled type 1 diabetes\u00a0 and obesity. However, nearly 50% of the cases are idiopathic (due to unknown etiology).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Mesenchymal Stem-Cell Remodeling of Adsorbed Type-I Collagen\u2014The Effect of Collagen Oxidation<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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Komsa-Penkova R, Stavreva G, Belemezova K, Kyurkchiev S, Todinova S, Altankov G<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Article Number: Int J Mol Sci. 2022 Mar 11;23(6):3058. IF 6.208 Q1<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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11 March 2022<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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In addition to their regenerative activity, mesenchymal stem cells (MSCs) are highly involved in extracellular matrix (ECM) remodeling . MSCs are multipotent stem cells (often referred to as adult stem cells) residing in most tissues poised to repair damage associated with trauma and ageing . As such, they are of great interest for most cell-based therapies . Adipose tissue-derived MSCs\u2019 (ADMSCs) diverse differentiation capacity and immunomodulatory activity combined with their relative abundance, accessibility and low donor site morbidity render them particularly attractive therapeutic agents.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Altered Mesenchymal Stem Cells Mechanotransduction from Oxidized Collagen: Morphological and Biophysical Observations<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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Regina Komsa-Penkova; Adelina Yordanova; Pencho Tonchev; Stanimir Kyurkchiev; Svetla Todinova; Velichka Strijkova; Mario Iliev; Borislav Dimitrov; George Altankov<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Article Number: Int. J. Mol. Sci. 2023, 24, 3635. IF 4.67 Q1<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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11 February 2023<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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The extracellular matrix (ECM) initiates several mechanical cues that are able to activate intracellular signaling events through cell\u2013matrix interactions. It is generally agreed that the quality and quantity of ECM determine its physical parameters, affecting cellular response, which also applies to the behavior of stem cells . Each organ or tissue provides specific mechanical cues that have to be understood in the context of the entire multicellular organization .<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Quality of life after transanal total mesorectal excision in rectal cancer patients \u2013 A single-center initial experience<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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M.Karamanliev, D. Dimitrov<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Article Number: 24: 48-294.Q1<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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13 September 2022<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Questionnaires were filled from 15 patients (93.75%), two patients were operated on in less than 3 months and did not fill the postoperative questionnaires. A total of 13 patients were included in the analysis. We analyzed the results from the preoperative questionnaire and the last available one.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Assessment of students' satisfaction with virtual robotic surgery training<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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\u00a0T. Kalinov, T. Georgiev, K. Bliznakova, A. Zlatarov, N. Kolev<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Article Number: e12839 3,4 Q1<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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January 2023<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Nowadays, in Bulgaria there is a trend of increasing entry into the surgical field of robot-assisted surgery operations, which suggests a need for the establishment of a large number of specialists in this field in a short period. Based on these arguments, the Medical University of Varna was the first university in the country to introduce a robotic surgery training program for medical students. The study aims to investigate the medical students\u2019 satisfaction on robotic surgery training provided at Medical University of Varna with da Vinci Skills Simulator.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Blood Plasma Calorimetric Profiles of\nWomen with Preeclampsia: Effect of Oxidative Stress<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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Regina Komsa-Penkova; Sashka Krumova; Ariana Langari; Ina Giosheva; Lidia Gartcheva; Avgusna Danailova; Lora Topalova; Tanya Stoyanova; Velichka Strijkova; Alexey Savov and Svetla Todinova l<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Article Number: IF 6,2 Q1<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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12 February 2023<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Purse-string failure at the beginning of the learning curve\nin transanal total mesorectal excision. European Journal of Surgical Oncology<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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\u00a0Marn Karamanliev, Tsvetomir Ivanov, Tsanko Yotsov, Emil Filipov, Tashko Deliyski, Dobromir Dimitrov<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Article Number: Volume 47, Issue 2, e49. Q1<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

A study on tumour-infiltrang lymphocytes, PD-L1 and BRCA1 immunohistochemical expression in basal-like subtype of breast cancer \u00a0P. Dimitrova, S. Popovska, I. Ivanov Article Number: 479 (Suppl 1):S1\u2013S320; PS-02-009, S68 IF…<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-16116","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/davinci-center.eu\/new\/wp-json\/wp\/v2\/pages\/16116","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/davinci-center.eu\/new\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/davinci-center.eu\/new\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/davinci-center.eu\/new\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/davinci-center.eu\/new\/wp-json\/wp\/v2\/comments?post=16116"}],"version-history":[{"count":64,"href":"https:\/\/davinci-center.eu\/new\/wp-json\/wp\/v2\/pages\/16116\/revisions"}],"predecessor-version":[{"id":16190,"href":"https:\/\/davinci-center.eu\/new\/wp-json\/wp\/v2\/pages\/16116\/revisions\/16190"}],"wp:attachment":[{"href":"https:\/\/davinci-center.eu\/new\/wp-json\/wp\/v2\/media?parent=16116"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}